Can I take sumatriptan and ibuprofen together?
Sumatriptan with painkillers
If your first dose of sumatriptan doesn't work to relieve your migraine, it's fine to take a painkiller containing aspirin, paracetamol, or a non-steroidal anti-inflammatory drug (NSAID), such as ibuprofen.
Taking Imitrex with other drugs
For example, they may recommend pain medications, such as: acetaminophen (Tylenol) acetaminophen, aspirin, and caffeine (Excedrin) nonsteroidal anti-inflammatory drugs (NSAIDs), such as naproxen (Aleve) or ibuprofen (Advil)
„„Other pain relief medicines such as paracetamol and ibuprofen can be taken 30 to 60 minutes before a triptan medicine.
You should not use this medicine if you have used an MAO inhibitor (MAOI) such as phenelzine (Nardil®) or tranylcypromine (Parnate®) within the past 2 weeks. Do not use this medicine if you have taken other triptan migraine medicines or ergot-type medicines within the past 24 hours.
Ibuprofen is an effective treatment option for migraine headaches. To treat a migraine headache, a person can take 400 mg of ibuprofen every 6–8 hours. A person can safely take ibuprofen with paracetamol and other types of migraine medications, such as triptans.
If your migraine or cluster headaches get worse, or happen more often than usual, talk with your doctor about ways to prevent them. Also talk with your doctor if you're using Imitrex to treat more than four headaches a month.
For migraine headaches: Adults—25, 50, or 100 milligrams (mg) as a single dose. If you get some relief, or if the migraine comes back after being relieved, another dose may be taken 2 hours after the last dose. Do not take more than 200 mg in any 24-hour period.
If your OTC medicines haven't worked, your doctor may prescribe stronger medications called triptans, including: Almotriptan (Axert) Eletriptan (Relpax) Frovatriptan (Frova)
This medicine may increase your risk of having abnormal heart rhythm, heart attack, angina, or stroke. This is more likely to occur if you or a family member already has heart disease, if you have diabetes, high blood pressure, high cholesterol, or if you smoke.
Headaches that are not relieved by sumatriptan are sometimes caused by conditions that need other treatment. If you feel much better after a dose of sumatriptan, but your headache comes back or gets worse after a while, wait at least 2 hours before taking another dose.
How many hours does sumatriptan last?
How long do sumatriptan side effects last? Sumatriptan is a short-acting medication with a half-life of around two hours. A sumatriptan dose will be completely cleared from the body in 10 hours.
Some patients report worsening of the headache or an unpleasant change in its character. This usually lasts for 10 to 30 minutes, but may continue for several hours. Others said the headache recurs within a few hours of initial relief and a second dose is needed after which the migraine usually subsides.

Interactions between your drugs
No interactions were found between sumatriptan and Tylenol.
There is a reason behind the limit on pills. Headache doctors know that taking triptans more than 10 times a month can actually make migraines more frequent or more severe in some people. Rebound headache, or medication overuse headache, is a pretty common migraine trigger.
It is not a painkiller but you can use this medicine if painkillers or non-steroidal anti-inflammatory drugs (NSAIDs) have not worked. Sumatriptan comes as tablets, a nasal spray or injection. The nasal spray and injection are used to treat migraines and cluster headaches.
Using these medicines together may cause serious unwanted effects. Make sure your doctor knows about all the medicines you are using. Sumatriptan and naproxen combination may cause a serious condition called serotonin syndrome when taken with some medicines.
Interactions between your drugs
No interactions were found between Advil and sumatriptan.
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