Can I take Advil while taking Imitrex?
No interactions were found between Advil and Imitrex.
No interactions were found between ibuprofen and sumatriptan.
No interactions were found between ibuprofen and Imitrex.
„„Other pain relief medicines such as paracetamol and ibuprofen can be taken 30 to 60 minutes before a triptan medicine.
Your doctor may recommend that you take Imitrex along with other medications to treat your migraine symptoms. For example, they may recommend pain medications, such as: acetaminophen (Tylenol) acetaminophen, aspirin, and caffeine (Excedrin)
No interactions were found between Imitrex and Tylenol.
Sumatriptan with painkillers
If your first dose of sumatriptan doesn't work to relieve your migraine, it's fine to take a painkiller containing aspirin, paracetamol, or a non-steroidal anti-inflammatory drug (NSAID), such as ibuprofen.
Headaches that are not relieved by sumatriptan are sometimes caused by conditions that need other treatment. If you feel much better after a dose of sumatriptan, but your headache comes back or gets worse after a while, wait at least 2 hours before taking another dose.
...
They include:
- Atogepant (Qulipta)
- Erenumab (Aimovig)
- Eptinezumab (Vyepti)
- Fremanezumab (Ajovy)
- Galcanezumab (Emgality)
- Rimegepant (Nurtec)
Do not take any MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication.
What medications Cannot be taken with sumatriptan?
do not take sumatriptan if you are taking a monoamine oxidase A (MAO-A) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) or if you have taken one of these medications in the past 2 weeks.
Interactions between your drugs
No interactions were found between sumatriptan and Tylenol.

If your migraine or cluster headaches get worse, or happen more often than usual, talk with your doctor about ways to prevent them. Also talk with your doctor if you're using Imitrex to treat more than four headaches a month.
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